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Epidemiology, clinical features, and prognosis of elderly adults with severe forms of influenza A (H1N1.

Identifieur interne : 000262 ( Main/Exploration ); précédent : 000261; suivant : 000263

Epidemiology, clinical features, and prognosis of elderly adults with severe forms of influenza A (H1N1.

Auteurs : José Garnacho-Montero [Espagne] ; Antonio Gutiérrez-Pizarraya ; Juan A. Màrquez ; Rafael Zaragoza ; Rosa Granada ; Sergio Ruiz-Santana ; Jordi Rello ; Alejandro Rodríguez

Source :

RBID : pubmed:23496351

Descripteurs français

English descriptors

Abstract

OBJECTIVES

To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H1N1) admitted to the intensive care unit (ICU) and to identify independent predictors of ICU mortality.

DESIGN

Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H1N1) admitted to the ICU.

SETTING

One hundred forty-eight Spanish ICUs.

PARTICIPANTS

Individuals with influenza A (H1N1) confirmed using real-time polymerase chain reaction from April 2009 to July 2011.

MEASUREMENTS

Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population.

RESULTS

One thousand one hundred twenty individuals (129 (11.5%) aged 65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, Acute Physiology and Chronic Health Evaluation II score (odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.11–1.20, P = .002), immunosuppression (OR = 3.66, 95% CI, 1.33–10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02–10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98–5.91, P = .06).

CONCLUSION

Individuals aged 65 and older with influenza A (H1N1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.


DOI: 10.1111/jgs.12152
PubMed: 23496351


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Case-Control Studies (MeSH)</term>
<term>Chronic Disease (epidemiology)</term>
<term>Comorbidity (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (mortality)</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Logistic Models (MeSH)</term>
<term>Male (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Prognosis (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Survival Analysis (MeSH)</term>
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<term>Analyse de survie (MeSH)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Comorbidité (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Maladie chronique (épidémiologie)</term>
<term>Modèles logistiques (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Pronostic (MeSH)</term>
<term>Répartition par âge (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Études cas-témoins (MeSH)</term>
<term>Études prospectives (MeSH)</term>
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<term>Antiviral Agents</term>
<term>Oseltamivir</term>
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<term>Spain</term>
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<term>Influenza, Human</term>
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<term>Influenza, Human</term>
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<term>Grippe humaine</term>
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<term>Unités de soins intensifs</term>
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<term>Grippe humaine</term>
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<term>Antiviraux</term>
<term>Oséltamivir</term>
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<term>Espagne</term>
<term>Grippe humaine</term>
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<term>Aged</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
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<term>Humans</term>
<term>Incidence</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Multivariate Analysis</term>
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<term>Analyse multifactorielle</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Répartition par âge</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H1N1) admitted to the intensive care unit (ICU) and to identify independent predictors of ICU mortality.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>DESIGN</b>
</p>
<p>Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H1N1) admitted to the ICU.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>SETTING</b>
</p>
<p>One hundred forty-eight Spanish ICUs.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>PARTICIPANTS</b>
</p>
<p>Individuals with influenza A (H1N1) confirmed using real-time polymerase chain reaction from April 2009 to July 2011.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>MEASUREMENTS</b>
</p>
<p>Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>One thousand one hundred twenty individuals (129 (11.5%) aged 65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, Acute Physiology and Chronic Health Evaluation II score (odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.11–1.20, P = .002), immunosuppression (OR = 3.66, 95% CI, 1.33–10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02–10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98–5.91, P = .06).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>Individuals aged 65 and older with influenza A (H1N1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.</p>
</div>
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<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H1N1) admitted to the intensive care unit (ICU) and to identify independent predictors of ICU mortality.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H1N1) admitted to the ICU.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">One hundred forty-eight Spanish ICUs.</AbstractText>
<AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Individuals with influenza A (H1N1) confirmed using real-time polymerase chain reaction from April 2009 to July 2011.</AbstractText>
<AbstractText Label="MEASUREMENTS" NlmCategory="METHODS">Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">One thousand one hundred twenty individuals (129 (11.5%) aged 65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, Acute Physiology and Chronic Health Evaluation II score (odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.11–1.20, P = .002), immunosuppression (OR = 3.66, 95% CI, 1.33–10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02–10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98–5.91, P = .06).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Individuals aged 65 and older with influenza A (H1N1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.</AbstractText>
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<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
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<DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
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<Investigator ValidYN="Y">
<LastName>Cobo</LastName>
<ForeName>Pedro</ForeName>
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<Investigator ValidYN="Y">
<LastName>Martins</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Carbayo</LastName>
<ForeName>Cecilia</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Robles-Musso</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cárdenas</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fierro</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fernández</LastName>
<ForeName>Dolores Ocaña</ForeName>
<Initials>DO</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sierra</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Huertos</LastName>
<ForeName>Ma Jesús</ForeName>
<Initials>MJ</Initials>
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<Initials>J</Initials>
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